48 Comments
User's avatar
Steve Belleci's avatar

Great Info. I would add Nattokinase as that saved me after a Heart Attack.

Michael LeVesque's avatar

And of course tart cherries.

Susan Clack's avatar

I want to send this to my cardiologist. I just relented and went on a low dose Statin after refusing for several years as my LDL numbers kept going up. Looks like I've really got work to do now!!

Leskunque Lepew's avatar

One of the things that puzzles me is that the human body makes 80% of the cholesterol needed. So 20% comes from nutrition. Look it up.

How can the lowering of cholesterol LDL be a good thing?

No doctor that I know has been able to produce an answer to this....they just toe the line.

Rick Zammuto's avatar

Most MD's throughout NA are forced to prescribe statins by the AMA and Canadian Colleges of Physicians and Surgeons throughout Canada (that should be abolished). I was once in a court case where the AMA lied about an MD and removed his license. I got the judge to make the AMA liars return his license and make them pay the $50M fine out of their own pockets. However, cases like this seldom go to trial anymore because big pharma mafia control everything.

Rick Zammuto's avatar

Most bad things from statins for me went away when I dropped to only 10mg every few days only when eating lean, grass-fed beef.

Surak's avatar

The best predictive metric from your lipid panel is the ratio triglycerides divided by HDL; you need to get that below 2. You can do that with a low-glycemic diet (lowering trigs), and exercise plus avocados (raising HDL).

A study has shown that moderately elevated LDL level does not predict heart disease for a physically active patient on a low-glycemic diet.

Finally, all-cause mortality was (EDIT): minimized in one study for patients with total cholesterol between 180 and 270.

Sam Clark's avatar

I have been looking at cholesterol as part of my deep dive into hypertension..

I came across this scientist being interviewed on a podcast. You might enjoy her also..

https://www.zoeharcombe.com/2024/12/how-accurate-is-your-cholesterol-test/

Fred's avatar

My triple drug HTN evaporated abruptly when I started VitD supplementation (for a non healing L1 fx). Spent 1 ½ weeks in a recliner, tapering my drugs. Looking back, because of other symptom resolution like chronically dry lips, I had been D deficient for decades. Others won’t see the same results, but there was a study that showed D as effective as the mild anti-HTNsives. Lasted for more than a decade.

Fred's avatar

Gradually ended back up on triple therapy, gradually weaned off all BP meds after starting a ketogenic diet. Glucose intolerance also resolved. Started the diet to support my spouse who suffered from familial migraines; very beneficial, although not perfect (he does waiver more than I do). 😁🙋‍♀️ Do women have more will power?

Fred's avatar

P.S. Traumatic L1 fracture that hadn’t healed in 1 ½ - 2 years also healed over about 4-6 weeks.

Sam Clark's avatar

Sounds like you are on the right road. Most hypertensive patients seem only to have to address metabolic issues like their insulin resistance, VitD, Mg, diet, weight, exercise etc and they come good. For me they were already in play and pretty much always have been. So am still looking for root cause which apparently can be endothelial and kidney related. I have started experimenting with DMSO cautiously to see how it reacts with the ACE inhibitor I am still on. I have to be my own doctor because doctors no longer heal (if they ever did) they just pimp for Big Pharma..

Fred's avatar

Let us know how that works out for you! Allow me to remind folks that serum Mg levels are a very poor reflection of cellular levels; shoot for upper range of “normal.”

Sam Clark's avatar

After reading up on Statins the last couple of years, I have come to the conclusion they are just another monumental scam which only causes harm. They deplete you of CoQ10, a fuel for heart muscle cells. We are already heavily depleted by the time we reach 50 so that is reason enough not to be on a Statin. When reading the studies on Statins they appeared flawed and manipulated which is so often the Big Pharma norm.. As usual with these pharmaceuticals, they do not address root cause but seem to purposely avoid the the issue altogether in favour of symptom maintenance which is of course what keeps them in business.

Fred's avatar

“Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review”

https://bmjopen.bmj.com/content/6/6/e010401

“Our study suggests that statin therapy…does not decrease the proportion of small, dense LDL among total LDL particles, but in fact increases it… and reduces absolute amounts of large, buoyant LDL.

https://pmc.ncbi.nlm.nih.gov/articles/PMC2929871/

Michael LeVesque's avatar

Thanks Sayer for a wonderful article!

As Linus Pauling would say, it is inaccurate to list the cause of death as a heart attack when the cause is a vitamin C deficiency. Of course many other wonderful nutrients help, such as, ubiquinol, l-carnitine, l- proline, magnesium orotate, and your list that goes on and on.

Rick Zammuto's avatar

This very accurate, great post should be seen by most MD's, and many others. I have told every MD I've talked to for decades that "plaques are not the cause of heart disease but the result of the body’s repair process to reinforce and mend weakened vascular tissue". Only one cardiologist listened 5 years ago because she knew "I was smart" by telling her things about her own field she did not know. I expect substack's Dr. Mark Trozzi knows the content of most of this post and he will perhaps read it today for a great summary. I do every vitamin you mention every day and others (except only 2g supplemental C with lots of organic fruits instead). The most important supplement I noticed was not mentioned here being NATTOKINASE (100mg2kfu), taken 2-4 hr after supper. I got that tip from substack's cardiologist Dr. Peter McCullough. He also says statins can reduce strokes in those 70+ years old, and I have seen other articles showing this is a small but real effect.

The Hidden Life Is Best's avatar

I did a huge deep dive into Vit C a few months ago as a treatment for heart disease (it runs in my family) and I was unable to find a single physician that is treating patients with it. Even Dr. Matthias Rath, Pauling's partner before Pauling's death, and a strong advocate for Vit C therapy for heart disease no longer uses it or even mentions it. The newest proponents, called "orthomolecular medicine" at the Riordan Clinic, around a man named Andrew Saul, who has many videos on youtube about it - https://www.youtube.com/watch?v=W5Bgdqsorg0 doesn't advocate it specifically for heart disease

Andrew Saul sadly died recently at age 68 of congestive heart failure. It looks like the great Pauling was wrong on this one. https://isom.ca/article/in-memoriam-andrew-saul/

The best assessments of the many benefits of Vitamin C and they are great and many does not list Vitamin C for heart disease - see the incredible work of Dr. Frederick Klenner

https://vitaminc.co.nz/pdf/CLINICAL-GUIDE-TO-THE-USE-OF-VITAMIN-C-FREDERICK-KLENNER-MD.pdf

Heart disease is a mystery. It's causes are many. Vitamin C can't hurt. Thanks for all your hard work.

Dr Joseph's avatar

This isn't exactly true. Heart disease isn't a mystery; it is a diagnosis that includes a variety of cardiac conditions, not just what vitamin C is implicated for.

Pauling didn't get it wrong; he just didn't live long enough to get to the bottom of the issue.

And that issue is collagen synthesis. Cardiac Tissue is comprised of collagen, and it is the highest concentration of collagen in the entire body, more so even than joints. While Vitamin C is the key catalyst in collagen creation, it is entirely possible and plausible that there is a genetic defect that prevents some people from making it properly, or enough to meet demand.

Further, the fat soluble form of vitamin C, which has been used since the 1950s in commercial applications is far more effective in cardiac conditions than just L-ascorbic acid or even the ascorbates. Also, we must consider the synergistic effects of niacin with vitamin C in vascular and cardiac health.

To say Vitamin C isn't effective for "heart disease" is disingenuous because heart disease is not just ONE thing, and Vitamin C plays a major factor in cardiac failure, but not the only one. I'll stop here because I will write for hours on this.

Sayer Ji's avatar

I agree that vitamin C is only one of a wide range of critical causes and 'cures.' Thanks for your input!

Dr Joseph's avatar

Keyword: "cures" in quotations.

There is a bigger discussion here regarding the mythology beyond the word "cure".

jennifer dibley's avatar

Hmmm I have evidence of collagen formation deficiencies. Hideous stretch marks from first pregnancy receding gums with good dental care fixed with lasers early facial wrinkling fixed with lasers peels and injectables aortic arch plaques and stiffening ,chronic a fib and mild heart enlargement. Joint problems and sjogrens I will be doubling up on my VitaminC intake and adding some form of lemons limes oranges and kiwis daily Will add bone broth for collagen and turmeric and vitamin E and daily olive oil for blood thinning (can’t take Eliquis because of chronic fissure/bleeding ) Hope to see improvement Question how does omr improve plaques and stiffening of aortic arch without dislodging plaque and causing stroke or heart attack

Barbara Charis's avatar

The primary cause of all disease is malnutrition; either not getting the nutrients one needs or destroying the body by ingesting non-nutritive items, which get into the bloodstream and damage the internal organs, glands and cells; processed foods, drugs, tobacco, etc.

Mankind lived many thousands of years in the beginning or we would not be here today,,,and this should provide answers. How did humans survive without any of the information that we have available? Number #1 Soil is Life! The soil today is almost gone and what is left has little nutritional value.. In order to survive, we really need to demand our government focus on restoring and regenerating our soil. The pesticides being used so freely are killing organisms in the soil, which provide nutrients to the crops; and the wrong fertilizer is totally lacking in all the nutrients that humans need for health. When the soil is gone, humans will be gone, too.

WIlliam J. Muir's avatar

Bro, the same conditions are created by chronic inflammation as well. You can dose vitamin C all you want but if you are not eliminating sources of inflammation you are still at a high risk of heart disease. It’s also likely that low vitamin C leads to heart disease because it causes inflammation. The key is learning to recognize inflammation and what causes it. Eliminate those things and you will progressively feel younger and healthier.

Chris Buchanan's avatar

This was terrific information, thank you. I’m curious - you mentioned citrus to structure water. Do you think adding herbs such as fresh parsley or mint would be beneficial to structure water?

Dr Joseph's avatar

There is a lot of irony to the whole "heart disease" thing.

1) "Heart disease" is not "one thing"; there are dozens of conditions lumped under the "Cardiovascular Disease" (CVD) umbrella and some of these conditions may be unrelated to a cardiovascular condition, in and of itself, such as hypertension and hyperlipidemia .

2) With regards to the latter part of point #1, issues with blood pressure and cholesterol (if these things really are issues in the first place) are the result of endocrine system function. Cardiologists, as a whole, know very little about the endocrine system, yet it is the kidneys and adrenals that control the RAA process that regulates blood pressure, and the liver processes excessive cholesterol. However, the standard of practice is to "treat" the vascular system via HBP meds and statins, when the actual cause is from an adjacent, regulatory body system. This is a failure of the medical community, on all sides, that refuses to recognize the intimate relationship between organ systems.

3) Vascular scorbusis is one of the causes of several types of Cardiovascular disease, but not all. So, to say that Vitamin C "doesn't work" for heart disease is false, because the end result in every case of vitamin C deprival is, ironically enough, heart disease. Congenital disorders, structural damage, and other common causes of CVD and congestive heart failure may only be related to C deficiency on the periphery.

4) The biggest reason why Vitamin C therapy is not indicated for heart disease and cancer and other big ticket diagnoses is because the industry cracked down on Vitamin-C-As-Treatment for name-brand diagnoses. It was cutting into the profits of the industry because people were, in fact, recovering. My experience corroborates this notion, and the very mention of Vitamin C therapy can result in a cease-and-desist.

Dr Joseph's avatar

It is next to impossible to convince the vast majority of people in the West of the critical nature of Vitamin C and the diseases caused by its deficiency or insufficiency because it does not fit into the modern medicine diagnostic linear model. It, in fact, contradicts the major tenets of medicine as we are taught, because it is the absence of the nutrient, as well as how poor human beings are at utilizing it, that leads to essentially every one of the "chronic diseases" as they are classically defined. One of the flaws in the way the medical community utilizes vitamin C is that they treat it like a "drug" that is used to "treat" conditions instead of understanding it as a building block to life for multicellular lifeforms.

Vitamin C needs to be administered in a certain way, meaning, it must be intaken to mimic the way mammals produce it for humans to find the true benefit. Few people, if any, actually mention that mammals are by far and away the most prolific producers of Vitamin C, and that human beings don't make a single drop of it. So, this means that we should be using C in the same way that mammals do, however, unfortunately, there isn't anyone doing any research on this because the end result would not be financially beneficial. The lack of Vitamin C research in the past 35 years is purely based on money. No one wants to invest in it because they can't profit from it.

Yvonne's avatar

Wow, that is a lot of information and research. Thank you.

Brenda Rapoport's avatar

Awesome truth as always Sayer Ji

Fotis's avatar

Comprehensive article! Thank you!

Barry Morgan's avatar

Outstanding information source.

Chris's avatar

Vitamin C is good if non GMO and you don't miss more then a day or youll rebound to low in C,and your bodies ability to extract from food will be much reduced,true for many vitamins, minerals too..This can occur to fast scurvy level,meaning your better off never starting Vit C supps unless you stay in them..Going over 1500 mg C a day is inviting minor scurvy if you don't stay on it.

Chris's avatar

Typo: ...vit K2 or magnesium is pure solution...