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Dana Ray's avatar

Thanks for this post Sayer Ji! I read this paper when it came out and my first thought was 'oh no'! I've taken glucosamine chondroitin with MSM for many years and am one of those folks whose stiff and achy joints have been relieved by this supplement. Good to read your detailed analysis.

denise ward's avatar

Glad you covered it however anything that comes from that rag ought to be ignored outright. Once a liar always a liar. The Washington Post is one paper that would never be on my reading list. Why waste time with lies and manipulations when we could be reading articles from those who speak truth in everything they say. We ought to make the mainstream papers obsolete by ignoring them entirely. What they cover is meant for you to see.

Hypernoia's avatar

So one should expect the approval coming down the pike of a new patented monopoly big pHarma drug with toxic side effects that they intend to replace glucosamine with on the market.

Mare Rich's avatar

Oh God. You could be right. Someone may be strategising....

STH's avatar

Thank you for clearing this up. I’ve taken glucosamine/Chondroitin for years for my arthritic thumbs. I was tempted to stop after hearing about the Nature Study, but I really feel it when I don’t take it. So I don’t care! And I also do not trust their studies anymore.

Copernicus's avatar

I have developed a heavy bias at this point that anything MSM or medical-industrial complex tells me might be dangerous is probably helpful, and anything they tell me is miraculous (hello, toradol for acute abdominal pain due to perf'd appendix) is probably dangerous.

[Seriously, they wanted to give me tordadol in ED and as part of in-op pain management, yet of course would not think of giving post-op NSAIDS due to risk of bleeding. Never mind the horrible adverse effect protocol of the med. I said "no."]

Mare Rich's avatar

Bravo Copernicus. If I see my GP I do the opposite to what s/he advises. Its very reliable!!!!

No reply's avatar

I’m gonna buy some ASAP!!

Mike Casey's avatar

Another potentially helpful therapy is sometimes portrayed as ineffective. Some people now argue that this is happening with glucosamine, just as they believe it happened with hydroxychloroquine and ivermectin. To them, it seems that inexpensive or off-patent treatments often receive far more criticism than expensive new products.

I believe ozone water faces a similar challenge.

In my own experience, ozone water has been very effective for cleaning minor skin injuries and helping keep wounds clean. I have personally observed rapid healing without signs of infection in my own use. Yet discussions about ozone often focus almost exclusively on ozone gas, which can irritate the lungs and cause coughing at high concentrations.

Ozone gas and ozone dissolved in water are different applications with different exposure considerations, but they are often discussed together. As a result, many people hear only that “ozone is toxic” without distinguishing between inhaling ozone gas and using freshly prepared ozone water for sanitation purposes.

Consider chlorine. Chlorine gas is hazardous at high concentrations, yet chlorine compounds are widely used to disinfect drinking water, swimming pools, and many household products when used appropriately. Ozone also has powerful disinfecting properties and breaks down rapidly into oxygen after use. Despite this, ozone water receives far less attention in healthcare than it does in industries that rely on high levels of sanitation.

I believe the medical system is often slow to adopt approaches that fall outside established practice. Whether that is due to regulatory requirements, limited clinical evidence, economics, or other factors is open to debate. Regardless, I think ozone water deserves more careful research rather than being dismissed outright.

Ozone water is extremely effective at reducing microorganisms on surfaces and in the immediate environment. Reducing contamination through good sanitation is a fundamental part of reducing the risk of infection. That concept has long been accepted in healthcare and many other industries.

My own experience has been encouraging. I have been drinking freshly prepared ozone water and using it in my daily sanitation routine for about ten years. During that time, I have not experienced a sore throat, significant illness, or skin infection. That is my personal experience, it is one reason I continue to study and advocate for ozone water.

If inexpensive approaches that improve sanitation and reduce reliance on medications prove to be effective, they could have a significant impact on healthcare costs. That possibility alone makes ozone water worthy of objective investigation.

I encourage you to look beyond headlines and learn about ozone water for yourself. Read the available research, examine real-world applications in industries that use it every day, and ask why it has received so little attention in medicine.

For more information, visit SourcePoint Environmental at sourcepointenv.com.

Medical Disclaimer: I am not a physician, and this information is not medical advice. I am a water expert, and my comments are derived from my own experiences, observations, and work with ozone and water treatment technologies. Ozone water products are discussed in the context of sanitation and preventative practices, and any references to prevention refer to general hygiene and sanitation measures rather than the prevention of specific diseases. These products are not approved to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider regarding medical decisions.

Mare Rich's avatar

Ozone is part of Biological Dentistry and very helpful.

Mike Casey's avatar

Ozone water is used in dentistry and many industries that require extreme sanitation.

BUT it’s not allowed in medicine, the one industry where it is seriously needed.

What does that tell you?

Mare Rich's avatar

Tells me that its likely healing...!!

tRuth's avatar

Yep. My biodentist includes its use, in all her surgeries. You go along with her safety protocol, or go elsewhere. Her mission is to heal your body. Whole health recovery is a proven when the oral cavity is dealt with integratively/functionally.

Mike Casey's avatar

I refuse to go to a dentist that doesn’t use ozone. It’s a sure sign that they don’t keep up with technology.

tRuth's avatar

Haha, technology. You could argue, ozone is the creators technology!

Why oh why, do so many snub things like water and oxygen!!

Mare Rich's avatar

And a big thanks to Mike Casey for bringing it up!!

Mare Rich's avatar

Fantastic.

Would you recommend this Dentist? I’m seeking a bio- implantologist - if you know of one?

tRuth's avatar

I used this dentist to eliminate the mercury and extract a tooth 'butchered' in my teens, that had got bad bacteria at the site of the dental pin, he hammered in, after the crevice was drilled out, no anaesthesia, (didn't even realise that was a possibility in dentistry until my thirties), the tooth finally broke at the back, falling away as cleaned teeth, over 40yrs later. No implants.

Can't tell you the wellness restoration last decade, by the phenomenal doc at:

https://weybridgebiodentist.co.uk/

The clinic was closer to me back in those days, 2hrs by car, roughly. It may be easier for you in it's current location.

I did so much research into availability of these options and categorically, would not have gone to any other clinic at the time on this land.

Make contact, look into your options.

NB: It now seems another clinic in Yorkshire, May be worthy. They also endorse red light therapy (this is the site I learned of him from: https://uk.boncharge.com/pages/scientific-advisory-board

Dr Lomas..... scroll down to find)

Mare Rich's avatar

Thank you soooooo much for these wonderful links. I do hope they might help others too. At least one other person is liking!!!

Funnily enough I saw Bita Fox about 8 years ago. She is reknowned for her use of ozone and for safe amalgam removal. I had a consultation and appreciated her set up. However I went with one of her contemporaries due to her long waiting list and the time frame was getting urgent for me with infection present …. so I had extractions but no replacement teeth not even partials at the time and have some lost jaw muscle (but am working on it). I had 15 amalgams (I know….!!!). He did some beautiful restorations which other Dentists have commented on which makes me feel good(!) . I am so grateful to have had an extension of function for 8 years. However the amalgam effect has caught up with the remaining molars and infection is present in those roots. So extractions are due and replacement with something is my next project requiring thought….

Love the red light therapy. I was onto this through Sarah Ballentine pHd.

(The Paleo Mom) xx

tRuth's avatar

Before my initial consultation, and following a dentist leaving the practice, I received a phone call, they were after refunding my deposit. I expressed horror, offering to take late notice cancellations, etc, but with a minimum of 2hrs advance warning to me for the commute.

They kept my deposit, ringing me within a couple of weeks. I'd total faith in Bita and she knew it.

So, you saw the Bedfordshire clinic in that wonderful location. The new location, seems to have many more associates on board.

Bita would certainly advise on your current protocols, and quote for extractions. I believe replacements are quoted later, but temporary teeth were still an option.

Of course, the decision will be yours, however must impose in your, that due to me having such amazing results, I would not consider future treatment of necessary, anywhere else. I could always take my red light bullet torch with me! ;-)

Elaine Seinfeld's avatar

sounds similar to CDS ( chlorine dioxide)

Mike Casey's avatar

It is similar to chlorine dioxide in the way it works. Ozone water is easier to use and has far more applications, however.

Mike Casey's avatar

Yes, I drink it every day. It is the best tasting water and it prevents illness.

I drink a glass of fresh ozone water every morning, first thing. You can feel the blast of oxygen wake you up. Then I make my coffee with it because it eliminates any bitterness and makes a smooth tasting coffee. I fill my thermos with it several times a day, taking a gulp of fresh ozone water each time. I haven’t had a sore throat in 10 years since I started drinking ozone water.

I highly recommend it.

Russell A. Paielli's avatar

I'd like to try it, but I am completely confused by your website, which says nothing about drinking it as far as I can see. Did I miss it? I don't care about using it to clean.

Also, are there any independent scientific sources on its benefits?

Mike Casey's avatar

You are correct. Somehow drinking it was missed in personal care. I will correct that.

Read the comments by Mare Rich. Mare posted a great study concerning the power of ozone water to promote good health.

The FDA approved ozone and ozone water as a food additive and a powerful organic disinfectant. Basically stating that it is safe to consume. It’s water and energized oxygen. How is this in any way problematic? Oxygen and water are the 2 most important elements for life.

Mare Rich's avatar

European Society of Medicine: Ozone Therapy: A Breakthrough in Medical Treatments

Ozone Therapy – An Unmatched Approach for Near Universal Prevention and Treatment

Robert Jay Rowen, MD

OPEN ACCESS

PUBLISHED: 30 June 2025

CITATION: Rowen, R., 2025. Ozone Therapy – An Unmatched Approach for Near Universal Prevention and Treatment. Medical Research Archives, [online] 13(6).

https://doi.org/10.18103/mra.v13i6.6523

COPYRIGHT: © 2025 European Society of Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI https://doi.org/10.18103/mra.v13i6.6523

ISSN 2375-1926

Mare Rich's avatar

Extraordinarily safe, ozone can be administered locally or systemically, or both, to any part of the body except lungs. OT improves oxygen delivery and uptake by a variety of mechanisms. It safely modulates inflammation by reducing inflammatory enzymes and raising anti-inflammatory cytokines and mediators. OT activates the critical Nrf2 transcription pathway, whose functions include crucial antioxidant enzyme production, DNA repair, mitochondrial protection and biogenesis, protein folding, anti-aging, and more. OT preconditioning protects the organism against chemical and infection stressors, and reperfusion injury. It has adjunct uses in the management of cancer, and may slow aging processes and degenerative disease, particularly skeletal by local injection. OT has significant utility in dentistry for prevention, treatment, repair and regeneration, including articular cartilage.

Because ozone is not patentable for profit, and would clearly challenge the current medical paradigm of disease maintenance drug therapy, it remains a “pariah” to drug-promoting regulatory authorities, while it could address the urgent universal need for safe, effective, and non-resistance promoting approaches to infectious diseases and “superbugs,” including generally untreatable viral disease. OT suffers from the “tomato effect” in that mainstream medicine shuns it, even where conventional medicine has dangerous approaches or no answers at all.

Mare Rich's avatar

I was delighted to find glucosamine for my joints years ago.... until I quit gluten. End of joint pain!! No meds needed. xx

tRuth's avatar

I looked into the Glucosamine/Chondroitin supplements, many of which also included a small amount of MSM. While researching what that actually is, stumbled across Stephanie Senneff, fairly certain it was her who believes, is the MSM doing the heavy lifting here. Sulphur pathways may be affected by glyphosate. So here's the loop: non-organic flour based baked goods, potentially aren't only grown in soils impoverished by the substance, but also grains are treated with glyphosate as a dessicamt.

Had knee surgery in 30's, now in 60's, never returned for further scrapes until knee replacement required.

Yeah, I'm grain free!

Mare Rich's avatar

Yay! Grain free is cool. I am too ...mostly. Just had a bit of rice but its rare. Dr Mercola has done a piece about how pretend joint ops have the same recovery rates as actual op. So... you're better off xx

tRuth's avatar

No! I wish though. My son had a French gf, we visited the family, in rural Brittany, north of Rennes, stayed in grandparents farm house, so much land too. It was awesome. Strangely, both her maternal grandparents were 80 within days of each other, married think it was sixty years, her brothers birthday, cousin too, as well as graduating college. Neighbours made traditional sourdough in their own clay ovens, which they bought daily to each meal, meats all locally sourced, everything homemade, even the wine, cider and other drinks, and so it goes on. Then came the day to meet her father, ugh, she'd already told me about him, so i knew enough, we met his mum who had own town bakery before retirement. Dad was chief registrar at Renne City Council. We did have a wonderful walking tour of the best sights though. Ugh.... was he a sleeze creature though. Unfortunately earlier that year, I'd suffered an extreme bereavement, my vocal coach, so I'd gotten a tad run down and suffered some strange symptoms that slowed me down. Might also have been EMF induced while taking ferry from Poole to St Malo. Water is a conductor and the boat, a metal container. So.....

Then, my son, moved from Cardiff to Barcelona with her, that had many French restaurants. That's where the best pancakes were.

I do love Europe for many reasons.

tRuth's avatar

Placed root canals are never ok!

It's been removed now: but there was a free to watch movie, made by the sufferer, called, 'Root Cause', it was excellent. I think you can still see the trailer though.

Yep, she was amazing, so confident for a teenager, but i didn't actually need persuading, although the second opinion, was just proof positive of what the animals try to do.

I have a now retired nursing (44yrs) sister. Tried to persuade her to finish during 2020, when she refused to be furloughed (oh the hospitals were overflowing according to the media), so ended up on Covid Exclusive ITU. She eventually finished in summer '22, when ic first saw her some 6/7 months later, she looked so well, I thought she'd had some facial work. She wasn't impressed with me, but did immediately say, 'It's called retirement! It feels great! I'm not discussing anymore, as NOW realise, been involved in evil.'

My goodness! However, we've caught up in this and many other evil topics through recent years. Wonder what all those frequencies are doing, or is it just the shift system, preventing the third eye from seeing?

Mare Rich's avatar

Yes I saw Root Cause. Bit sexist but still had value.

Hope your sister is ok.

tRuth's avatar

Good! Nothing sexist to me! Considered it could have been somewhat exaggerated in parts, but hey, The proof is in the fact it's been taken down.

My sister is what she is, affluent, got money to dispose of, which is due no children, senior role, same goes with her husband. Unsure about him, although I've seen redemption with sister!

Michael LeVesque's avatar

Thanks Sayer for this excellent analysis!

It seems that journals continue to publish hit pieces on nutritional supplements. It is their mode of operation. Nature and Scientific American will discuss any subject and leave out nutritional therapies. The largest studies will do the same all because of access and price.

Wonderful glucosamine an amino sugar used by the body to create cushioning fluids and tissues around joints. It repairs damaged arthritic joints, reduces pain, and builds synovial fluids. It is easily absorbed in the bloodstream, and is necessary in the formation of skin, eyes, bones, tendons, nails, ligaments, and parts of the heart. It is used for inflamed discs, sciatica, and many forms of arthritis. It is necessary in the production of mucous as a protective coating in the urinary, digestive, and respiratory tracts.

One finds glucosamine sulfate, and n-acetyl glucosamine in the marketplace as inexpensive alternatives to many prescribed drugs laden with the usual litany of bad effects. You become your own healer when using it and that's bad for allopathic business.

Arizona Scottsdale's avatar

When do we get a study about advertisers influencing the press?

Nelly feist's avatar

Thanks for clarifying the article.

On another note, (I heard on The Highwire) is it true that Stand for Health Freedom supported the Bill in Florida that criminalizes Naturopathy?!! Can you please address this, thanks again,

Nelly

Hypernoia's avatar

SO PREDICTABLE.. looky here…. (this was a gemini AI prompt, though I could not share the link as attachments not allowed)

what are the most common medical conditions that people use glucosamine to treat?

—-

By far, the most common reason people take glucosamine is to manage osteoarthritis (OA) and general joint wear-and-tear.

National Center for Health Research

Because glucosamine is a natural compound found in healthy joint cartilage, the theory is that supplementing it can help maintain or rebuild that cushioning. However, people also use it for a handful of other related musculoskeletal and inflammatory issues.

Arthritis Foundation+ 1

Here is a breakdown of the most common conditions it is used for, along with what the clinical evidence actually says:

1. Osteoarthritis (OA)

This is the primary target for glucosamine use. It is most frequently taken for OA of the knee, though people also use it for OA of the hip, spine, and hands.

Mayo Clinic

The Goal: Users hope to reduce joint pain, stiffness, and slow down the progressive breakdown of joint cartilage.

Arthritis Foundation

The Reality: The clinical data is highly mixed. Large, high-quality independent studies (like the NIH's landmark GAIT trial) generally show that glucosamine doesn't perform much better than a placebo for mild pain, though it might offer mild-to-moderate relief for some individuals with severe knee pain. Interestingly, it is classified and prescribed as a regulated medical treatment in many European nations, while in the US it is sold over-the-counter as a dietary supplement.

Harvard Health+ 1

2. General Joint Pain and Stiffness

Many athletes, aging adults, or individuals with physically demanding jobs take glucosamine reactively for everyday joint aches or proactively to protect their joints from heavy impact.

The Goal: To preserve joint lubrication and prevent premature cartilage degradation.

The Reality: There is little definitive evidence that taking glucosamine prevents joint disease in completely healthy joints, though its mild anti-inflammatory properties may provide subjective relief for minor aches.

3. Rheumatoid Arthritis (RA)

Mayo Clinic

While osteoarthritis is caused by mechanical wear-and-tear, rheumatoid arthritis is an autoimmune condition characterized by systemic inflammation of the joint lining. Some people take glucosamine hydrochloride to manage RA symptoms.

Mayo Clinic

The Goal: To lower overall joint discomfort alongside standard prescription therapies.

The Reality: Early research suggests it may help reduce subjectively perceived pain, but clinical trials note that it does not actually reduce joint swelling, inflammation, or change the underlying progression of autoimmune joint damage.

4. Temporomandibular Joint (TMJ) Disorder

TMJ causes pain and dysfunction in the jaw joint and the muscles that control jaw movement. Because the jaw relies on a cartilage disc for smooth movement, some individuals use glucosamine to manage chronic jaw pain.

The Goal: To reduce jaw clicking, stiffness, and localized pain.

The Reality: A few small studies have found that glucosamine performs similarly to low-dose ibuprofen for managing TMJ pain, though larger scale data is still lacking.

Important Nuances to Keep in Mind

Formulations Matter: Glucosamine is typically sold in two primary forms: Glucosamine Sulfate and Glucosamine Hydrochloride (HCl). Most clinical trials showing positive effects have specifically used glucosamine sulfate (often combined with chondroitin sulfate).

Mayo Clinic

Safety: It is generally considered safe for long-term use, with mild stomach upset being the most common side effect. However, because many commercial glucosamine supplements are harvested from the exoskeletons of shellfish, anyone with a severe shellfish allergy should look for vegan or plant-derived alternatives.

National Center for Health Research

—-

are there any new drugs pending FDA approval to treat osteoarthritis?

—-

Yes, there are several highly anticipated, innovative therapies currently moving through the FDA pipeline. For years, osteoarthritis (OA) treatments have been limited to symptom management (like painkillers and steroid injections). However, the current pipeline features a major shift toward long-acting biologics, regenerative medicine, and gene therapies designed to either provide durable pain relief or actively halt joint degeneration.

GoodRx+ 1

The most notable treatments pending approval or entering late-stage FDA review include:

1. ReNu® (Amniotic Suspension Allograft)

BioSpace

Status: Under Active FDA Review (Biologics License Application accepted July 2026).

http://Barchart.com

FDA Action Date: April 24, 2027.

BioSpace

How it works: ReNu is a cryopreserved (frozen) injection consisting of amniotic fluid cells and micronized amniotic membrane. Rather than just masking pain, this biologic therapy leverages natural growth factors and extracellular matrix components to reduce inflammation and support the joint environment. It is aimed at patients with symptomatic knee OA who want to delay or avoid total knee replacement.

BioSpace

2. GNSC-001 (Gene Therapy)

http://Barchart.com

Status: Phase IIb/III clinical trials starting in 2026; holds FDA RMAT (Regenerative Medicine Advanced Therapy) and Fast Track designations.

BioPharm International

How it works: This is a potentially first-in-class gene therapy. It uses a modified viral vector to deliver a gene that expresses a naturally occurring protein called interleukin-1 receptor antagonist (IL-1Ra). Because interleukin-1 is a primary driver of the inflammation and cartilage destruction in OA, a single injection into the joint is designed to turn the knee into a long-term factory for its own defense, providing sustained protection and pain relief.

BioPharm International

3. MM-II (Liposomal Suspension)

Pharmacy Times

Status: Moving into Phase III development with FDA Fast Track designation.

BioPharm International

How it works: MM-II is a non-opioid, intra-articular (intra-joint) injection that utilizes a proprietary suspension of liposomes. It essentially acts as an ultra-durable, bio-lubricant for the knee joint, reducing mechanical friction and providing meaningful, long-lasting relief from physical wear-and-tear without the systemic side effects of steroid shots.

Pharmacy Times

4. PCRX-201 (Enekinragene Inzadenovec)

http://Barchart.com

Status: Early-stage data showing up to two years of efficacy; holds FDA Fast Track designation.

BioPharm International

How it works: Another gene therapy candidate delivered via a single local injection. Recent multi-year follow-up data from its clinical trials has shown sustained improvements in knee pain, mobility, and stiffness by down-regulating inflammatory pathways directly inside the joint capsule.

BioPharm International

The Structural Shift: The FDA's heavy reliance on designations like Fast Track and RMAT for these joint therapies underscores a major push to fast-track disease-modifying osteoarthritis drugs (DMOADs)—treatments that actually change the course of the disease rather than just dulling the pain.

Mare Rich's avatar

Thanks for sharing. I may have had a glucosamine deficiency. It helped a lot to start with but then the benefits tapered. Going gluten-free seems to have addressed the problem for me.

Mlanghaar's avatar

What if you’re allergic to shellfish or vegan?

Bitch TOK 4$5's avatar

those w half a brain know the gimmicks Lucifer and it's dumbass gifts pour down our throat and some are smart enough not to ingest said gimmicks

Marlena's avatar

What does the mainstream push about Lucifer??

Bitch TOK 4$5's avatar

off my page Marlena if reality is an option