In this thought-provoking talk, recorded in 2020, Sayer Ji takes us on a journey into the microscopic world of exosomes—nanoparticles secreted by our own cells that, under the microscope, are often indistinguishable from viruses. This striking similarity raises profound questions: Are viruses actually exosomes? Or have we misinterpreted their role in biology altogether?
For centuries, human health has been framed through the lens of germ theory, which views microbes as invaders to be fought and eliminated. Yet with the rise of advanced imaging technologies and the blossoming field of microbiome research, this model has begun to unravel. What once appeared to be pathogens may, in fact, be vital participants in the symphony of life.
Sayer explains how exosomes act as molecular messengers, carrying genetic information between cells, organisms, and even across kingdoms of life. From plants to animals, this constant horizontal exchange of information supports resilience, regeneration, and adaptation. What we once viewed as harmful contagion may instead be a language of survival—a system of communication that has shaped evolution for millions of years.
He also points out that our very existence is tied to viruses. Segments of our DNA, including those that made the mammalian placenta possible, are retroviral in origin. Far from being destructive outsiders, viruses and exosome-like particles are embedded within our biology, contributing to immunity, genetic diversity, and the ongoing cycles of renewal.
Seen in this light, modern fear-based narratives around invisible “enemies”—whether framed through epidemics, vaccines, or public health policies—begin to resemble myths more than science. By contrast, this “new biology” reveals a world in which microbes are partners rather than predators, collaborators rather than threats.
At its core, Sayer’s message is one of empowerment: when we understand exosomes and viruses not as foes, but as vital components of life’s regenerative system, we can move beyond fear and toward a deeper appreciation of the intelligence woven into the fabric of nature.
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